Talk:Domoic acid

Chemicals Low‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Low	This article has been rated as Low-importance on the project's importance scale.

Medicine: Toxicology Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.
	This article is supported by the Toxicology task force (assessed as Mid-importance).

Is domoic acid responsible for most forms of ASP, or only some? Mentioning red tides suggests it is produced mainly by dinoflagellates, but information on the web links it mainly to diatoms.

Red tides and red algae are not synonymous. Red tides are so named for their visual appearance (reflectance) red algae are so named for their photochemistry (absorbance), these are opposite uses of the same adjective. —Preceding unsigned comment added by 198.123.41.42 (talk) 21:14, 4 August 2008 (UTC)[reply]

Response: Domoic acid is the phycotoxin responsible, specifically, for ASP (Amnesic Shellfish Poisoning); there is only one "form". It is produced by some diatoms and some red macroalgae, but not by any dinoflagellates (so far). The term "Harmful Algal Bloom" (HAB) has often replaced the more commonly known descriptor, "red tide".

AMPA and kainate are pharmacologic agents used to distinguish between different glutamate receptor subtypes. The physiologic neuotransmitter that they respond to is glutamate, AMPA and Kainate are not produced in the brain. For clarity, I would suggest referring to them as "glutamate receptors (AMPA/kainate subtype)".

It is "commercially available" for what purpose?

Comparing the structure of domoic acid shown on this page, there is no information on the configuration of the chiral center at the CH-COOH group (should be (R)), and also the first double bond in the side chain is shown as (E) - which is wrong - instead of (Z). see: [1]

-- Krakatit (talk) 15:53, 21 June 2008 (UTC)[reply]

I second the comments from Krakatit - the structure as shown on the article page is wrong/incomplete. The structure should be as given in the Aldrich link he provided and as confirmed in the STN databases (CAS# 14277-97-5). Name as given by STN/CAS for this substance with this Registry number, the L-form:

    3-Pyrrolidineacetic acid, 2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-, (2S,3S,4S)-

and which is the substance referred to in the literature (1010 references in STN currently). As a new user I am unable to upload the corrected structure; perhaps an established user/editor could? (Chimia69 (talk) 17:50, 18 January 2009 (UTC))[reply]

The correct structure is shown here: http://www.chemspider.com/Chemical-Structure.4445428.html--ChemSpiderMan (talk) 03:23, 11 April 2009 (UTC)[reply]

I am retracting the comment about the structure above being the correct structure. I am seeing conflicting information now about E/Z orientation and am working to figure it out. --ChemSpiderMan (talk) 15:01, 14 April 2009 (UTC) All is well - everything is checked[reply]

I notice that the structure has been updated with stereochemistry for the side chain methyl. However, the E/Z stereo is still incorrect. I will update the structure this evening. --ChemSpiderMan (talk) 01:31, 15 April 2009 (UTC)[reply]

1/100th amount toxic to nerves is toxic to kidneys

Even at 1/100 the level toxic to nerves, demoic acid appears to be toxic to the kidneys.

"Posted: 07 Feb 2014 05:36 AM PST Domoic acid accumulates in seafood and is toxic to the brain. Research indicates that the toxin damages kidneys at concentrations that are 100 times lower than what causes neurological effects."

^[1] dcebr 13:24, 8 February 2014 (UTC)

References

^ http://www.sciencedaily.com/releases/2014/02/140206155248.htm

External links modified

Hello fellow Wikipedians,

I have just modified one external link on Domoic acid. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

Added archive https://web.archive.org/web/20131204023151/http://www.inter.dfo-mpo.gc.ca/Gulf/DAPR to http://www.inter.dfo-mpo.gc.ca/Gulf/DAPR

When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at {{Sourcecheck}}).

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 03:27, 15 December 2016 (UTC)[reply]

Federal limit

The article says 20 mg / kg tissue, but that figure does not make any sense. The source says part per million, could someone change it? — Preceding unsigned comment added by 24.18.38.178 (talk) 02:26, 5 February 2018 (UTC)[reply]

Questionable History Section Addition

A news article came out and claimed seals are attacking people because of this chemical from algae blooms. I'm unsure if people think this source and speculation is worth adding.

Source JackW2 (talk) 05:16, 1 July 2023 (UTC)[reply]

[1] ttp://www.sciencedaily.com/releases/2014/02/140206155248.htm

[1]